O'Connor was born in New Rochelle, New York, and is the daughter of actress Lenka Peterson and film producer Daniel Patrick O'Connor. She is married to Douglas Stern, a New York City native, and they have two daughters together, Lindsay (b. 1990) and Hana.
In 1973, O'Connor sang the title song for the film Jeremy in which she also co-starred with Robby Benson. On January 8, 1974, she starred in the CBS Radio Mystery Theatre production of "Ring of Roses" and then co-starred with John Travolta in the 1976 made-for-television movie The Boy in the Plastic Bubble. The same year she portrayed Bobbie Lee Hartley, co-starring again with Robby Benson, in the film Ode to Billy Joe, a tragic romance produced and directed by Max Baer Jr.
In 1984, O'Connor starred as Leola Mae Harmon in the biographical made-for-TV movie Why Me?, about United States Air Force nurse Harmon's trauma and series of facial reconstruction surgeries after a horrifying car accident. She was also cast in 1984 in the comedy Johnny Dangerously. In 1986, O'Connor performed in the NBC made-for-TV movie The Deliberate Stranger.

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