Grammer was born on February 15, 1992, in Los Angeles, California to actor Kelsey Grammer and make-up artist Barrie Buckner. Her parents were never married. Through her father, she has three half-sisters: Spencer (born 1983), Mason (born 2001), and Faith (born 2012) and three half-brothers: Jude (born 2004), Gabriel (born 2014), and James (born 2016). She was raised primarily by her mother in Malibu, California. She was named after actress Greer Garson.
Grammer became passionate for theater at a young age, participating in various plays from the age of 5 before competing in pageants as a teenager. She attended Idyllwild Arts Academy for two years, receiving training under their theater program. She graduated from the University of Southern California in June 2014 as a theater major. She is also a member of the Delta Tau chapter of the Kappa Kappa Gamma sorority.
Grammer served as Miss Golden Globe 2015 at the 72nd Golden Globe Awards.

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