He also appeared in a minor role as James, the Fiancé in the 2020 Netflix miniseries The Haunting of Bly Manor.
Sestero was born in Walnut Creek, California. His mother is of French and Italian (Sicilian) descent. He was raised in Danville, California, where he attended Monte Vista High School.
Sestero has said that he wrote a sequel to the then-recently released Home Alone at the age of 12, titled Home Alone 2: Lost in Disney World, which included a leading role for himself alongside Macaulay Culkin's Kevin McCallister. He submitted the screenplay, along with a provisional poster, soundtrack suggestions and a request for a cross-promotional deal between 20th Century Fox and Walt Disney Pictures, to Hughes Entertainment, and eventually received a commendatory letter from John Hughes. Sestero credits Hughes' gesture with inspiring him to pursue a professional acting career.

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