Harrison was born in Avalon, California, in 1950, the middle child of Ed Harrison, a ship's captain and poet, and Donna Lee Nagely, an aspiring dancer; they eventually divorced. He has an older sister, Kathleen (born 1948), and a younger brother, Christopher (born 1961). He served for two years in the United States Army during the Vietnam War era as a medic.
He was the title character on the science fiction series Logan's Run (1977-78), after which he played Levi Zendt on the NBC miniseries Centennial (1978).
He appeared on an episode of M*A*S*H before garnering fame in 1979 with the role of surgeon Dr. George "Gonzo" Gates on Trapper John, M.D., starring opposite Pernell Roberts. The medical drama was spun off from M*A*S*H. Harrison remained as Gonzo on Trapper John until the middle of the show's seventh season, when he decided to leave for other ventures. The series continued for several more episodes without Harrison, but concluded its run at the end of the 1985–86 season.[citation needed]

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