Matarazzo was born and raised in Oyster Bay, New York, the daughter of Camille, a homemaker, and Ray Matarazzo, a data processing manager for a bakery chain. Matarazzo is of Irish descent, and was adopted and raised by the Matarazzos, a strict Catholic Italian American family.\n', '

Matarazzo began acting at the age of six; after commandeering the microphone at an AIDS benefit for children, she was given the card of a talent manager with whom she remained for ten years.\n', '

In 1997, she won an Independent Spirit Award for her performance in Welcome to the Dollhouse. Matarazzo has expressed pleasure in being allowed to play interesting characters, some of whom "are ostracized for various reasons." She has commented that she is most proud of her performance in 1999\'s Our Guys: Outrage in Glen Ridge, in which she played a mentally challenged girl who is raped by football players. In 1999 to 2000 she portrayed Heather Wiseman in the short-lived TV series, Now and Again. In 2000 she appeared in the teen romantic comedy film The Princess Diaries as Lilly Moscovitz and reprised her role in the 2004 sequel The Princess Diaries 2: Royal Engagement.\n', '

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