McDonald was born in 1970 in the San Fernando Valley, to real estate agent parents. She is of three quarters Irish and one quarter French-Canadian descent. She and her brother and sister were raised Catholic and attended private, Catholic schools. After high school, McDonald went to the University of Southern California (USC), where she was a member of the Gamma Phi Beta sorority.\n', '

After graduating from USC, McDonald began to take theatre classes at The Groundlings. During her time there, McDonald performed improvisational shows and sketch comedy at the Groundlings Theatre. At the same time, McDonald became a licensed realtor like her parents.[citation needed]\n', '

In the late 1990s, McDonald began writing with Keenan Ivory Wayans. In 2001 and 2002, she was a writer and performer for MTV\'s Lyricist Lounge. She made an appearance on Frasier as one of Frasier\'s many blind dates.\n', '

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