Charrière was born at Saint-Étienne-de-Lugdarès, Ardèche, France. He had two older sisters. His mother died when he was 10. At 17 in 1923, he enlisted in the French Navy and served for two years. After that, he became a member of the Paris underworld. He later married and had a daughter.
The version of his life presented in his semi-biographical novel, Papillon, claimed that Charrière was convicted on 26 October 1931 of the murder of a pimp named Roland Le Petit, a charge that he strenuously denied. He was sentenced to life in prison and ten years of hard labour. He had married Georgette Fourel at the town hall of the 1st arrondissement of Paris, on December 22, 1929. (They divorced on 8 July 1930 by decision of the Paris High Court.) After a brief imprisonment at the transit prison of Beaulieu in Caen, France, he was transported in 1933 to the prison of St-Laurent-du-Maroni on the Maroni River, in the penal settlement of mainland French Guiana.
According to the book, he made his first escape on 28 November 1933 and was joined by fellow prisoners André Maturette and Joanes Clousiot, who would accompany him throughout much of his time on the run. Thirty-seven days later, the trio were captured by Colombian police near the village of Riohacha, northern Caribbean Region of Colombia, and were imprisoned. Charrière subsequently escaped during a rainy night and fled to the La Guajira Peninsula, where he was adopted by an indigenous tribe. He spent several months living with the natives, but felt that he had to move on, which was a decision he would ultimately regret. After leaving, he was quickly recaptured and sent back to French Guiana to be put into solitary confinement for the next two years.

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