Wehmeier attended Western Hills High School (Cincinnati, Ohio). Signed by the Cincinnati Reds out of high school, he went on to play 16 years in the major leagues.
He led the National League in Walks Allowed in 1949 (117), 1950 (135) and 1952 (103). He led the NL in Earned Runs Allowed (145) in 1950. He led the NL in Wild Pitches in 1949 (7) and 1950 (11). He led the NL in Hit Batsmen (7) in 1952. In 13 seasons he had a 92–108 Win–loss record, 240 Games Started, 79 Complete Games, 9 Shutouts, 9 Saves, 1,803 Innings Pitched, 794 Strikeouts, and a 4.80 ERA. As a hitter, he posted a .196 batting average (124-for-633) with 67 runs, 3 home runs and 40 RBIs.

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