Straczynski wrote the psychological drama film Changeling (2008) and was co-writer on the martial arts thriller Ninja Assassin (2009), was one of the key writers for (and had a cameo in) Marvel's Thor (2011), as well as the horror film Underworld: Awakening (2012), and the apocalyptic horror film World War Z (2013).
From 2001 to 2007, Straczynski wrote Marvel Comics' The Amazing Spider-Man, followed by runs on Thor and Fantastic Four. He is also the author of the Superman: Earth One trilogy of graphic novels, and he has written Superman, Wonder Woman, and Before Watchmen for DC Comics. Straczynski is the creator and writer of several original comic book series such as Rising Stars, Midnight Nation, Dream Police, and Ten Grand through Joe's Comics.
A prolific writer across a variety of media and former journalist, Straczynski is the author of the autobiography Becoming Superman (2019) for HarperVoyager, the novel Together We Will Go (2021) for Simon & Schuster, and Becoming a Writer, Staying a Writer (2021) for Benbella Books. In 2020 he was also named Head of the Creative Council for the comics publishing company Artists, Writers and Artisans.

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