Noseworthy earned a Bachelor of Fine Arts degree from the Boston Conservatory.
He appeared in Bon Jovi's music video "Always", with Carla Gugino and Keri Russell. He co-starred with Meryl Streep in the Public Theater's 2006 production of Mother Courage and Her Children.
He starred in a short-lived MTV drama series, Dead at 21. In December 2005, he originated the role of Armand in the musical Lestat during its pre-Broadway run at the Curran Theatre in San Francisco, but left the production during its first week of previews (he was replaced by actor Drew Sarich). He is also the only male actor to play Peter Pan on Broadway, in the revue Jerome Robbins' Broadway.

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