He was called up by the Arizona Diamondbacks from Tucson for the first time on June 8, 2007, when reliever Brandon Medders was optioned to Tucson. He made his major league debut that day in the ninth inning of a 10-3 loss to the Boston Red Sox, retiring the only three batters he faced, Jason Varitek, Coco Crisp, and Doug Mirabelli, in order.\n', '

On March 19, 2009 Peguero was released by the Diamondbacks.\n', '

Peguero signed a minor league contract with the Los Angeles Angels of Anaheim before the beginning of the 2009 season. On May 19, 2009 Peguero was released by the Angels organization, as a member of the Salt Lake Bees. Peguero appeared in 16 games for the Bees in 2009, owning a 0-1 record with a 9.98 ERA with one save and 15 strikeouts.\n', '

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