Adomian was born in Omaha, Nebraska, on January 31, 1980, and raised in Atlanta, Georgia. His family moved to Los Angeles when he was ten years old. Adomian is an alumnus of Los Angeles Baptist High School and attended Whittier College studying in a self-designed major in Economics and Theatre Arts. He notes that he did not graduate during a 2017 interview with Pete Holmes. Adomian is of partial Armenian descent.
Adomian began appearing as President George W. Bush frequently on The Late Late Show after Craig Ferguson took over hosting the show in January 2005 until 2009.
He has appeared on several other comedy programs, including MADtv, Mind of Mencia, Jimmy Kimmel Live!, Short Circuitz, Atom TV, Cavemen, Recount and Players.

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