Gustave signed with the Houston Astros as an amateur free agent on May 25, 2010, receiving a $40,000 signing bonus. He spent his first two professional seasons with the Dominican Summer League Astros, and played for the Gulf Coast League Astros in 2012. In 2013, he pitched for the Greeneville Astros of the Rookie-level Appalachian League, pitching to a 2–3 win–loss record and a 2.68 earned run average (ERA). He played for the Quad Cities River Bandits of the Class A Midwest League in 2014, finishing the year with a 5–5 win-loss record and a 5.01 ERA.\n', '

After the 2014 season, the Boston Red Sox selected Gustave from the Astros in the 2014 Rule 5 draft, and traded him to the Kansas City Royals. During spring training in 2015, the Royals placed Gustave on waivers, and he was claimed by the San Diego Padres. The Padres then returned Gustave to the Astros before the start of the regular season.\n', '

Gustave pitched for the Corpus Christi Hooks of the Class AA Texas League in 2015. He pitched to a 5–2 record and a 2.15 ERA with 20 saves, and was named a postseason All-Star. The Astros added him to their 40-man roster after the season. Gustave began the 2016 season with the Fresno Grizzlies of the Class AAA Pacific Coast League, and was promoted to the major leagues on August 10.\n', '

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