Mayweather had a career boxing record of 32–10–5 (10 KOs). His biggest accomplishment was winning the IBO junior lightweight title from John Roby on April 21, 1994, a title which he defended two times. On March 13, 1993, Mayweather lost to Oscar De La Hoya, who was in only his 5th pro bout, by TKO in round 4.
After a successful career in the ring, Mayweather followed in the footsteps of his brothers and became a trainer. Known as the "Quiet Mayweather" Mayweather has trained several champions including Sultan Ibragimov, Celestino Caballero and for a short period Floyd Mayweather Jr.
On October 14, 2011, he led Caballero down to Argentina where they captured the WBA featherweight title from Jonathon Barros. Jeff Mayweather is current boxing coach for Pakistani Boxer Muhammad Waseem who is known to be Pakistan's first professional boxer to have ever held a WBC title. He is the Current WBC Silver Flyweight Champion.

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