The show begins with the couple having just moved to Houston, Texas, where the series has documented the customized building of their home and attempts to have a child. Arnold is a neonatologist who works at the Texas Children's Hospital, and Klein is a medical supplies and telemarketing businessman.
They were originally introduced in a one-hour TLC special, Little People: Just Married. Season 1 of the show premiered on May 26, 2009. Season 2 premiered on October 27, 2009. On February 22, 2010, TLC renewed The Little Couple for a third season consisting of 20 episodes. The mid-season finale aired after 9 episodes on July 27, 2010, and season 3 returned on October 12, 2010. It was announced on Facebook that the show would be returning for its 4th season on May 31, 2011. Again, the season was split, with the second half of season 4 premiering on September 27, 2011.
In February 2012, Klein opened Rocky&Maggie in Rice Village Houston. named after their pets Chihuahua Rocky and rescue mutt terrier Maggie. Arnold's mother Judy manages the store. Season 5 began on March 20, 2012, and follows Klein and Arnold as they move into their custom-built dream home and launch a brand-new business. In March 2013, they adopted their son, Will, from Hohhot, China. The adoption of their son, who also has dwarfism, is featured in Season 5. On October 15, 2013, they adopted a daughter, Zoey, also a little person, from Delhi, India. The series went into an hiatus on June 4, 2013, and returned on August 13, 2013.

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