DeShong's playing career lasted for 14 seasons (1928–1941). His MLB service saw him miss, by one year, two dynasties: the 1929–1931 Athletics and the 1936–1939 Yankees. However, he enjoyed a stellar campaign as a member of the 1936 Senators, posting an 18–10 won–lost record and finishing eighth in the American League in victories. His high win total in 1936 was accompanied by a mediocre 4.63 earned run average, and he permitted 255 hits (among them, 11 home runs) and 96 bases on balls in 223.mw-parser-output .frac{white-space:nowrap}.mw-parser-output .frac .num,.mw-parser-output .frac .den{font-size:80%;line-height:0;vertical-align:super}.mw-parser-output .frac .den{vertical-align:sub}.mw-parser-output .sr-only{border:0;clip:rect(0,0,0,0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}2⁄3 innings pitched, with only 59 strikeouts.
Overall, in his 175 games, which included an even 100 starts, he compiled a 47–44 record and a 5.08 career ERA, permitting 968 hits and 432 walks, with 273 strikeouts, in 8722⁄3 career innings pitched. He threw two shutouts and 44 complete games, and was credited with nine saves, then an unofficial statistic. On July 28, 1934, DeShong tossed a one-hitter against his former Philadelphia teammates, surrendering only a seventh-inning home run to Baseball Hall of Fame slugger Jimmie Foxx. He was a minor-league manager and a scout for the Athletics after retiring from the field.
Jimmie DeShong died at age 83 in Lower Paxton Township, Pennsylvania.

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