Lando attended Stevenson High School in Lincolnshire, Illinois.
His first acting role was as a patrolman in Star Trek IV: The Voyage Home. He received attention for his role as Jake Harrison in the soap opera One Life to Live, and went on to co-star in the popular drama Dr. Quinn, Medicine Woman as Michaela Quinn's love interest, Byron Sully. He also appeared in the television series Guiding Light and starred in Higher Ground, for which he also served as executive producer. He had a small part in the series Summerland, and appeared in eight episodes of the TV series The Secret Circle as John Blackwell, the father of the main character. In 2014 he joined several Dr. Quinn castmates as they all reprised their roles for the "Funny or Die" parody Dr. Quinn, Morphine Woman.
He has appeared in various feature films, including Seeds of Doubt (1996) and No Code of Conduct (1998). He reunited with Dr. Quinn costar, Jane Seymour, in 2011 for Hallmark Channel's Perfectly Prudence, and again in 2022 for Lifetime's A Christmas Spark.

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