Joseph Alberto Santiago (born June 10, 1965) is a Filipino-American guitarist and composer. Active since 1986, Santiago is best known as the lead guitarist for the American alternative rock band Pixies. After the band's breakup in 1993, Santiago produced musical scores for film and television documentaries, and he formed The Martinis with his ex-wife, Linda Mallari. He also contributed to albums by Charles Douglas and former Pixies band-mate Frank Black. Santiago resumed his role as the Pixies' lead guitarist when they reunited in 2004.
Santiago has described his guitar technique as "angular and bent", and he cites Les Paul, George Harrison, Chet Atkins, Wes Montgomery, Joe Pass and Jimi Hendrix as major influences on his style. His guitar playing, as part of the Pixies' sound, was held in high regard by critics: MTV's Laurel Bowman commented that Santiago's "sonic plow was the key element in the Pixies' monstrous presence".
Santiago was born in Manila, Philippines, on June 10, 1965, the third of six sons of an anesthesiologist. In 1972, when President Marcos declared martial law, the family immigrated to the United States. After two years in Yonkers, New York, the family moved to Longmeadow, Massachusetts, where Santiago attended Longmeadow High School and graduated from Wilbraham & Monson Academy in 1983. His first experience with a musical instrument was playing a Hammond organ at the age of eight, but he never took on the instrument seriously because he had to share it with five brothers. Santiago first played a guitar at the age of nine after he noticed a classical guitar hanging on his oldest brother's wall for decoration. The first song he learned to play was The Velvet Underground's "Rock and Roll".

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