Mayberry attended Northwestern High School, graduating in 1967. He was a gifted high school athlete, playing baseball, football, and basketball at Northwestern; John was twice named to the Detroit News All-State Basketball Team. After graduation, Mayberry was selected by the Houston Astros in the first round (sixth overall) of the 1967 Major League Baseball draft. He was the second first baseman taken in the draft, Ron Blomberg having been selected number one overall by the New York Yankees.\n', '

As an 18-year-old, Mayberry was assigned to the Covington Astros of the Appalachian League. While there, he batted .252 in the 1967 season, hitting 4 home runs in 155 at-bats. He continued to develop the following season, making appearances at three different levels of minor league baseball. His batting average for the 1968 season was a robust .320, with a high of .338 in 195 at-bats for the Cocoa Astros of the Florida State League. Between three levels, Mayberry hit 23 home runs and slugged .552. He made his major league debut that season, appearing in four games but amassing no hits. During his four-game call-up, Mayberry recalled the first time that he met Hank Aaron, who was playing for the Atlanta Braves:\n', '

At 20 years old, Mayberry played 123 games for the Oklahoma City 89ers of the AAA-level American Association. With 21 home runs, a .303 batting average, and a .522 slugging percentage, his power began to resemble the man he met the year before in the majors. He batted in 78 runs and scored 95, walking more times than he struck out (62/42). Mayberry\'s second short stint in the majors did not result in his first hit, though he did make it on base with one walk in five plate appearances. That would not come until the following year; after playing 70 games at Oklahoma City and batting .273 with 13 home runs, Mayberry was called up to the Houston Astros.\n', '

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