After graduating in 2001 with a Master of Business Administration degree from Mississippi State University, Knott was signed by Mal Fichman as an amateur free agent with the San Diego Padres. He made his major league debut on May 30, 2004. He became a free agent on December 12, 2006, after he was not offered a contract by the Padres. He signed a minor league contract with the Baltimore Orioles nine days later.\n', '

In 2006, Knott led the Pacific Coast League in home runs and RBI 32 and 113, respectively. Knott was the first Portland Beavers player to top the PCL in home runs since 1991 and he was the first Portland batter to win the RBI title in the leagues modern era.\n', '

Knott was recalled to the Orioles on June 23, 2007, to replace the injured Miguel Tejada. He was optioned back to the Norfolk Tides on June 29. He was recalled again on July 14, this time to occupy the roster spot vacated when third baseman Melvin Mora went on the disabled list. Knott was designated for assignment by the Orioles on September 9, 2007, and became a free agent at the end of the season.\n', '

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