Cisnero signed with the Houston Astros as an international free agent on December 6, 2007 and was added to their 40-man roster on November 20, 2012. He made his major league debut on April 22, 2013. In parts of two seasons for the Astros, he made 33 relief appearances, posting a 4.66 ERA with 46 strikeouts in .mw-parser-output .frac{white-space:nowrap}.mw-parser-output .frac .num,.mw-parser-output .frac .den{font-size:80%;line-height:0;vertical-align:super}.mw-parser-output .frac .den{vertical-align:sub}.mw-parser-output .sr-only{border:0;clip:rect(0,0,0,0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}48+1⁄3 innings. He was outrighted off the roster on November 3, 2014, and subsequently became a free agent.
On November 18, 2014, Cisnero signed a minor league deal with the Cincinnati Reds. Cisnero sat out the 2015 season due to Tommy John surgery. He elected free agency on November 6, 2015.
On December 21, 2015, Cisnero signed a minor league deal with the Arizona Diamondbacks organization . He was released on March 31, 2016, after failing to make the team in Spring Training.

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