Guillén was signed by the Pittsburgh Pirates as an amateur free agent on August 19, 1993. He made his Major League debut on April 1, 1997.\n', '

On July 23, 1999, Guillén was traded, along with Jeff Sparks, to the Tampa Bay Devil Rays for Joe Oliver and Humberto Cota. On November 27, 2001, after two injury-plagued seasons with the Devil Rays, the team released him.\n', '

On December 18, 2001, Guillén signed with the Arizona Diamondbacks. He played in only 54 games for the Diamondbacks before being released on July 22, 2002.\n', '

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