Mijares signed with the Twins as a free agent on March 2, 2002 and bounced around every level of the Twins\' farm system—having risen as high as the Triple-A Rochester Red Wings in 2007. He was awarded the Gulf Coast League Rolaids Relief Man Award in 2004 and elected as an All-Star in the Eastern League in 2007.\n', '

On January 24, 2008, he was re-signed to a one-year deal, and on March 9, 2008, he was cut from spring training and optioned to the Double-A New Britain Rock Cats of the Eastern League. He also spent part of the 2008 season with the Gulf Coast League Twins and Fort Myers Miracle before ended the minor league season again assigned to the Rock Cats.\n', '

In September 2008, Mijares received a call up to the Minnesota Twins, and made his major league debut on September 13 against the Baltimore Orioles. The Twins won that game 12–6. Mijares wound up becoming the Twins main set-up man for the remainder of the season.\n', '

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