She has played many roles, including portraying the parts of prostitutes, which were in strong contrast to her own wealthy upbringing as a billionaire's daughter. For the film Exiled, Ho did not work with a script. Recalling the experience in a recent interview, she said of director Johnnie To, "[He] basically tells actors what to do ... Johnnie wants us to come to the set with our mind completely clean, like a white piece of paper. That way, he can draw whatever he wishes on us." Ho starred alongside Eason Chan in the Pang Ho-cheung directed slasher film, Dream Home.
In 2009, Ho along with husband Conroy Chan, and Andrew Ooi, co-founded 852 Films, a film production company.
Ho is the youngest daughter of businessman Stanley Ho and Ho's second wife Lucina Lam. She has 3 older sisters and 1 younger brother, Pansy, Daisy, Maisy and Lawrence, as well as numbers of half-brothers and half-sisters.

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