Mosqueda-Lewis started playing basketball in the third grade. At first, she didn't like it, but she kept working at it. She played for the Tennessee Flight, a national club team, and qualified for the USA National U16 team, a team for under-16-year-olds.
Mosqueda-Lewis was named captain of her team, and helped lead them to the semifinals of the state tournament in 2009. She averaged over 24 points a game en route to a 31–0 regular season record. While still a sophomore, she was named the Gatorade player of the year for California, and named to the Parade All American list for the country.
Mosqueda-Lewis has led her team in scoring since her freshman year. As a junior, she was named the number one player in the country by ESPN's Hoopgurlz, while leading her team to a number one ranking among high schools in the country.

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