Duffy was raised Catholic, and is of Irish descent. She attended Park Ridge High School in Park Ridge, New Jersey, graduating in 1979. She received a bachelor's degree in recreational therapy from the University of Colorado Boulder.[citation needed]
By 1989, Duffy was modeling and appearing in television commercials. She was a VJ for MTV in the early 1990s, under the name "Duff." She had small roles in a handful of films including Dumb and Dumber and Blank Check, and by 1995 was working as a correspondent for documentary filmmaker Michael Moore on his television shows TV Nation and The Awful Truth. She also was a Revlon "Charlie Girl" as well as the face of Almay Cosmetics, and co-hosted the pay-per-view television event, Elvis: The Tribute from the Memphis Pyramid in 1994 with Kris Kristofferson.
In 2006, Duffy hosted House of Tiny Terrors on TLC. On July 7, 2007, she appeared on the Live Earth telecast on the Bravo Channel as a co-host at Giants Stadium, East Rutherford, New Jersey.

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