Karen Valentine (born May 25, 1947) is an American actress. She is best known for her role as young idealistic schoolteacher Alice Johnson in the ABC comedy drama series Room 222 from 1969 to 1974, for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series in 1970, and received a Golden Globe Award nomination in 1971. She later went to star in her own short-lived sitcom Karen (1975), and played leading roles in the Disney films Hot Lead and Cold Feet (1978) and The North Avenue Irregulars (1979).

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