Salem, who was born and raised in Los Angeles, is a 1973 graduate of Agoura High School in Agoura, California.
In 1997, Salem earned an Emmy Award as a writer for the television special Don King: Only in America, which also earned him a PEN nomination. The film also won the Broadcast Film Critics Award and Peabody Award for Best Television Film of the year. He received a second Emmy nomination the following year for writing The Rat Pack, in addition to a second PEN nomination. He also won as Brad Stephens in Hawaii Five-O season 8 episode, "The Deadly Persuasion".
In 1991, Salem won a Drama-Logue award for his performance in Richard Greenberg's The Extra Man at South Coast Repertory Theater, as well as a Boston Critics award for his performance as "Cousins" in George Bernard Shaw's Major Barbara with Cherry Jones at the American Repertory Theater in Cambridge. Salem also co-starred on Broadway as "Scoop" in The Heidi Chronicles with Mary McDonnel.

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