Karl Gajdusek was born in 1968 in San Francisco, California, United States.
Gajdusek's first professional break came through an option by independent producer Jeff Young for his screenplay Widow's Walk. Although the film would never be produced, Young's attempts to get the film made landed Gajdusek with his first agent. Gajdusek's next film, Higher was developed with director James Foley and later with director John McNaughton. For a period of time, Gajdusek teamed with screenwriter Michael Finch. Together they sold a number of pitches to various buyers including two to WWE Films. Their script based on the Bill Granger's The November Man novel, There Are No Spies, titled The November Man, first developed in 2009, began shooting in Belgrade in 2013 with Pierce Brosnan starring in the lead role. The film would finally premiere in 2014.
Meanwhile, Gajdusek wrote a solo feature script, Pandora, redefining him as a darker dramatic writer. After doing uncredited work on The Mechanic and the Liam Neeson film Unknown, Gajdusek wrote Trespass for Irwin Winkler which was released in 2011. Also in 2011, Gajdusek began work on two projects which would shape the direction of his career. The first was a screenplay based on the Rick Remender and Greg Toocchini graphic novel The Last Days of American Crime. Gajdusek claims it as one of his favorite pieces of writing. Director Olivier Megaton came on board in 2018 and the film will premier on Netflix in 2019.

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