Settle was born in Hawaii, the oldest of five children of Susanne (née Riwai), who is of Māori (Rangitāne, Ngāti Kahungunu) descent from New Zealand, and British-born David Settle. She is a graduate of Kahuku High School (class of 1994), and an alumna of Southern Utah University.
Settle made her Broadway debut in 2011 in Priscilla, Queen of the Desert as Shirley and in the ensemble.
Settle originated the role of Norma Valverde in Hands on a Hardbody, a musical which ran briefly on Broadway in 2013, and is based on the 1997 documentary about real people competing to win a new truck. The TheatreMania reviewer wrote: "Settle, as Norma, steals every scene she's in. The spectacularly bizarre lead-in to her big number, 'Joy of the Lord,' is more difficult to pull off than most Shakespearean monologues, and her solo vocals reveal a soulful, oversized gospel range that drives the Holy Spirit straight to the back of the theater. When she tearfully realizes what her faith in God may have wrought, it stings like a chigger bite. Settle's touching performance should go on the shortlist for every Best Featured Actress prize in town." For this role, Settle was nominated for the Outer Critics Circle, Drama Desk, and Tony Award for Best Featured Actress in a Musical. Additionally, she was awarded the Theatre World Award for Outstanding Broadway or Off-Broadway debut performance during the 2012-13 theatrical season.

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