Mella signed with the San Francisco Giants organization as an international free agent on May 31, 2012. He made his professional debut in 2012 with the Dominican Summer League Giants, recording a 3-3 record and 2.47 ERA in 14 appearances. Mella played the 2013 season with the AZL Giants, logging a 3-2 record and 2.25 ERA in 10 games. He split the 2014 season between the Single-A Augusta GreenJackets and the Low-A Salem-Keizer Volcanoes, pitching to a cumulative 4-4 record and 3.45 ERA with 83 strikeouts in 86.0 innings of work. He was assigned to the High-A San Jose Giants to begin the 2015 season.
On July 30, 2015, the Giants traded Mella and Adam Duvall to the Cincinnati Reds in exchange for Mike Leake. He finished the year with the High-A Daytona Tortugas, logging a 3-1 record and 2.95 ERA in 4 games with the team. In 2016, Mella split the year between Daytona and the Triple-A Louisville Bats, posting a 9-9 record and 3.76 ERA with 101 strikeouts in 138.2 innings pitched.
The Reds added Mella to their 40-man roster after the 2016 season. He split the majority of the 2017 season between the Double-A Pensacola Blue Wahoos and Louisville, accumulating a 9-4 record and 3.00 ERA in 21 games. On September 12, 2017, Mella was promoted to the major leagues for the first time. He made his MLB debut on September 20, pitching 2.0 innings of 2-run ball against the St. Louis Cardinals. He finished his rookie season with a 6.75 ERA across 2 appearances for Cincinnati. In 2018, Mella spent the majority of the year in the minors, and pitched in 4 big league games for the Reds, stumbling to an 8.68 ERA in 4 games. Mella played in Louisville for the majority of the 2019 season, and allowed 3 runs in 3.2 innings of work in 2 major league games. On November 4, 2019, Mella was outrighted off of the 40-man roster and elected free agency.

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