Spirtas is perhaps best known for his roles as Dr. Craig Wesley on the soap opera Days of Our Lives, Jonas Chamberlain on the ABC soap opera One Life to Live, and as Nick in the slasher film Friday the 13th Part VII: The New Blood (1988). Spirtas has worked on Broadway, with roles including Hugh Jackman's understudy in The Boy from Oz. He began using the name "Kevin Spirtas" professionally in 1995, having been previously credited as "Kevin Blair".
In 2015, Spirtas portrayed Dominic Delacort on the soap opera web series Winterthorne. In 2016, he was nominated for an Indie Series Award for Best Guest Actor in a Drama, and a Daytime Emmy Award for Outstanding Actor in a Digital Daytime Drama Series for the role.
Spirtas was born in St. Louis, Missouri, the son of Sandra, who is active in community politics, and Arnold Spirtas, who runs an environmental demolition company. Spirtas graduated from Ladue Horton Watkins High School in 1980.

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