Greene played high school baseball at Key West High School. Greene played all 69 games at third base for the Clemson Tigers in his freshman season, all but one of them starts. His first collegiate home run was an inside-the-park home run which came at the UNLV/Coors Desert Classic on February 27. In his freshman year, Greene had 98 hits, setting the record for Clemson freshmen. He led the team in hits, multi-hit games (31), at-bats (274), and hit-by-pitches (11). His batting average for the season was .358. Greene was a unanimous selection to the All-Regional Team in the postseason.\n', '

In his sophomore season, Greene started every one of the team\'s 69 games at third base. He led the team in batting average with runners in scoring position at .444. He was an All-ACC second team selection. (The first team selection was Georgia Tech\'s Mark Teixeira.) He was selected to the All-ACC Tournament team.\n', '

Greene again started every game for the Clemson Tigers in his junior season, but this time he and erstwhile shortstop Jeff Baker switched positions. He set the school record in season fielding percentage at that position (.965), while also setting every hit-by-pitch record for the school (in an inning, 2; in a game, 3; in a season, 21; in a career, 47). He also led the team in doubles with 18. He was named the ACC Player of the Week during the last week of the season. Peter Gammons made a prediction in his 2001 pre-draft column on ESPN.com: "You won\'t find Clemson shortstop/third baseman Khalil Greene or Wake Forest center fielder Cory Sullivan on any top-100 list, but check back in five years from now and see if they aren\'t remarkably like Jeff Cirillo and Steve Finley. Greene and Sullivan are players." Greene was drafted with the second pick of the fourteenth round (409th overall) by the Chicago Cubs, but did not sign.\n', '

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