Wetzel was born in Pittsburg, Texas, with one of his names being a reference to outlaw country singer-songwriter David Allen Coe. His mother was a touring country singer, bringing the young Koe along and his father worked in construction. He would perform on stage for the first time at age six. Later, Wetzel was a linebacker at Tarleton State University in Stephenville, Texas, where he decided to pursue a career as a musician instead.
Wetzel formed "Koe Wetzel and Konvicts", and self-released an EP and one full-length album. His "rowdy" music and lyrics became popular among college students and young adults, and Noise Complaint, released in 2016, was considered to be his breakout album. Beginning with Noise Complaint, the full name of the band was dropped, though Wetzel still performs with a bassist, one drummers, and two guitarists. The band signed with Red 11 Music in Austin, TX in early 2018 while being managed by 4-Tay Management out of Stephenville, TX until 2019 when the band signed a management deal with Floating Leaf Entertainment, establishing a joint venture between Wetzel and Jeb Hurt who had previously been the band's agent at Red 11 Music.
Harold Saul High was released in 2019 to mixed reviews, however sales were strong, and the album charted on the Billboard 200.

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