Renfroe pitched for the University of Mississippi where he set a school record for the most wins during his career. While in college, he experimented with a sidearm delivery, which he eventually adopted permanently. He was drafted by the Chicago Cubs in the 25th round of the 1984 Major League Baseball June Amateur Draft, and began the 1984 season with the Geneva Cubs.\n', '

After three seasons in Class-A ball, Renfroe split both the 1987 and 1988 seasons between the Double-A Pittsfield Cubs and Triple-A Iowa Cubs. Pitching for the Double-A Charlotte Knights of the Southern League in 1989, he led all minor league pitchers with 19 wins, and won the Southern League Pitcher of the Year award that season. He was promoted back to Iowa in 1990, and spent the following three seasons with the club.\n', '

He was called up to the Chicago Cubs on July 2, 1991, and made his Major League debut the following day at Wrigley Field against the Pittsburgh Pirates. He ultimately appeared in four games as a relief pitcher with Chicago, garnering a 0–1 win–loss record and a 13.50 ERA. He returned to Iowa on July 25.\n', '

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