They met at the University of Southern California where they were freshman roommates; they graduated from the School of Cinematic Arts in 1985.
Their first success was the popular but critically derided comedy Problem Child (1990). Alexander and Karaszewski claim that their original screenplay was a sophisticated black comedy, but that the studio replaced them and watered it down into an unrecognizable state. With the studio in a hurry to make a sequel, they returned to write Problem Child 2.
In 1992, dissatisfied with their career, they decided to write a biopic about Edward D. Wood, Jr. Rather than mocking him, they identified with the obscure filmmaker and his struggles. Tim Burton loved their script Ed Wood and agreed to direct it. They had written the screenplay in six weeks.

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