Castillo signed with the Philadelphia Phillies as an international free agent. He debuted in the Phillies\' minor league organization in 2007 as a shortstop. The Phillies converted Castillo into a pitcher in 2010, and he pitched for the Phillies\' organization in 2010 and 2011. He was used primarily as a starting pitcher in 2010 and as a relief pitcher in 2011.\n', '

The Cubs selected Castillo from the Phillies organization in the 2011 Rule 5 draft. Castillo made the Cubs\' Opening Day roster. Castillo was designated for assignment on January 26, 2013, to make room for Carlos Villanueva. He cleared waivers and was outrighted to the Triple-A Iowa Cubs. Castillo began the 2013 season with the Class-A Kane County Cougars.\n', '

On August 18, 2015, Castillo signed a minor league contract with the Toronto Blue Jays. He elected free agency on November 6, 2015.\n', '

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