Lewis W. Whistler (né Wissler; March 10, 1868 – December 30, 1959) was an American Major League Baseball player who played the majority of his career as a first baseman. In his four-season career, he played for the New York Giants (1890–1891), Baltimore Orioles (1892), Louisville Colonels (1893) and St. Louis Browns. His major league totals include: 272 games played, 1014 at bats, and a .244 batting average. Whistler died in his hometown of St. Louis, Missouri at the age of 91, and is interred at Bethany Cemetery in Pagedale, Missouri.

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