He is also particularly remembered as Ebenezer Scrooge in annual broadcasts of A Christmas Carol during his last two decades. He is also known for playing Dr. Leonard Gillespie in MGM's nine Dr. Kildare films, a role he reprised in a further six films focusing solely on Gillespie and in a radio series titled The Story of Dr. Kildare. He was a member of the theatrical Barrymore family.
Lionel Barrymore was born Lionel Herbert Blythe in Philadelphia, the son of actors Georgiana Drew Barrymore and Maurice Barrymore (born Herbert Arthur Chamberlayne Blythe). He was the elder brother of Ethel and John Barrymore, the uncle of John Drew Barrymore and Diana Barrymore and the great-uncle of Drew Barrymore, among other members of the Barrymore family. He attended private schools as a child, including the Art Students League of New York. While raised a Roman Catholic, Barrymore attended the Episcopal Academy in Philadelphia. Barrymore graduated from Seton Hall Preparatory School, the Roman Catholic college prep school, in the class of 1891.
He was married twice, to actresses Doris Rankin and Irene Fenwick, a one-time lover of his brother, John. Doris's sister Gladys was married to Lionel's uncle Sidney Drew, which made Gladys both his aunt and sister-in-law. Doris Rankin bore Lionel two daughters, Ethel Barrymore II (1908 – 1910) and Mary Barrymore (1916 – 1917). Neither child survived infancy. Barrymore never truly recovered from the deaths of his girls, and their loss undoubtedly strained his marriage to Doris Rankin, which ended in 1923. Years later, Barrymore developed a fatherly affection for Jean Harlow, who was born about the same time as his daughters. When Harlow died in 1937, Barrymore and Clark Gable mourned her as though she had been family.

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