Lisa Loomer was born in New York and moved to Mexico with her family in her late teens. She is of Spanish and Romanian ancestry. Loomer studied theatre at Brandeis University and New York University's Tisch School of the Arts.
Lisa Loomer began her career as an actress and comedienne. Her first work for theater was A Crowd of Two at the American Place Theatre. This was followed by a one-woman show, All By Herselves, at the Westside Arts Theatre. She began writing plays at the Intar Playwrights Lab, under the direction of Maria Irene Fornes. Her first play Birds was produced by South Coast Rep.
Lisa Loomer’s play Roe, about Roe v. Wade, was originally commissioned through the Oregon Shakespeare Festival's American Revolutions program. It was first produced at OSF in a production that traveled to Arena Stage and Berkeley Rep. It received the Jane Chambers Playwriting Award and the Pen Award.

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