Kebede has served as the WHO's Ambassador for Maternal, Newborn and Child Health since 2005.
Kebede was born and raised in Addis Ababa, Ethiopia. She is ethnic Amhara. She is the only daughter in the family, having four brothers. A film director spotted her while she was attending Lycée Guebre-Mariam, the school in which she learned fluent French, and introduced her to a French modeling agent. After completing her studies, she moved to France to pursue work through a Parisian agency. Kebede later relocated to the US, initially to Chicago then New York City.
Kebede's big break came when Tom Ford asked her for an exclusive contract for his Gucci Fall/Winter 2000 fashion show. Then in May 2002 she was on the cover of Paris Vogue, which dedicated the entire issue to her.

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