Greiner grew up in the Near North Side, Chicago. She majored in communications at Loyola University Chicago and worked for The Chicago Tribune while in college. She was an aspiring playwright and sold jewelry on the side. She is married to Dan Greiner.
Greiner is the president and founder of For Your Ease Only, which launched in 1996. The same year, she created and patented a plastic earring organizer; J.C. Penney picked up the product before the holiday season, allowing her to pay off her $300,000 loan in 18 months. In addition to jewelry storage, she has patented consumer products in categories such as cosmetic organization, travel, electronics, and household items. Greiner has invented hundreds of products and holds 120 patents.
After her success with J.C. Penney, Greiner expanded her company, with her products appearing on Home Shopping Network and in the retail store Bed, Bath and Beyond. In 2000, she began hosting a show on QVC, "Clever & Unique Creations by Lori Greiner". Her many appearances on the network led to her nickname, "The Queen of QVC".

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