DeVito was born on March 11, 1983, in Los Angeles, the daughter of actors Danny DeVito and Rhea Perlman. She also has two younger siblings, a sister, Grace Fan DeVito, and a brother Jacob Daniel DeVito. Her father is Catholic and her mother is Jewish.
She graduated from Brown University in 2007 with a degree in theater.
In 2008, DeVito starred as Anne Frank in a production of Anne Frank at the Intiman Theatre in Seattle, Washington.

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