He played in the Negro Leagues with the New York Black Yankees, Baltimore Elite Giants and Homestead Grays. In 1949 he became the first black player to sign with the New York Yankees. He played for 20 seasons in Puerto Rico\'s winter league. In a history of Puerto Rican baseball, Thomas Van Hyning described Márquz as "a complete ballplayer who could hit, run, throw, play good defense and provide power when needed." He is the all-time leader in hits (1,206), runs (768) and doubles (235).\n', '

Márquez played 14 seasons in the minor leagues. He played for the Portland Beavers in the Pacific Coast League and for the Milwaukee Brewers, the Toledo Sox, and the Dallas-Fort Worth Rangers in the American Association.\n', '

Márquez was involved in baseball throughout his life as player, coach, trainer, and Little League coach. The municipal baseball stadium in Aguadilla, Estadio Luis A. Canena Márquez, is named for him.\n', '

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