As a Little League Baseball player, the 12-year-old, 6 ft 2 in (1.88 m) Pisciotta used his overpowering fastball to lead the East Marietta National Little League of Marietta, Georgia, to the 1983 Little League World Series title.
Pisciotta attended George Walton Comprehensive High School and played college baseball at Georgia Tech. In 1990, he played collegiate summer baseball in the Cape Cod Baseball League for the Yarmouth-Dennis Red Sox and was named a league all-star. He was selected by the Pittsburgh Pirates in the 19th round of the 1991 MLB Draft.
Pisciotta was claimed off waivers by the Cubs after the 1996 season, and made his major league debut with Chicago on June 30, 1997. He appeared in 24 games for the Cubs that season, and in 43 games the following season. He was released by the Cubs prior to the 1999 season, and was picked up by the Royals, appearing in eight games for Kansas City in 1999, his final major league campaign.

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