Paredes began acting in 1960 film, 091 Policia al Habla (091, Police Speaking!) She became a teen idol across Spain after that film. In 1961, she made her début in theatre and since then she has performed different plays such as Hamlet with Eduard Fernández. In 1975, she and Raphael collaborated in a cartoon film about him, Rafael en Raphael. She has participated in 73 films and television series. She portrayed the leading role of La Peregrina in a television production of Alejandro Casona's La dama del alba.
Pedro Almodóvar helped her to achieve her international fame, as she starred many of his films. In fact, in Spain, she is called "una chica Almodóvar" ("an Almodóvar girl"). She appeared in High Heels (1991), The Flower of My Secret (1995), All About My Mother (1999) and The Skin I Live In (2011). For her role in The Flower of My Secret, she was nominated for the Best Actress Goya Award.
She has appeared in several other acclaimed films, including In a Glass Cage (1986) by Agustí Villaronga (Majorca), Life Is Beautiful (1998) by Roberto Benigni (Italy), Deep Crimson (1996) by Arturo Ripstein and The Devil's Backbone (2001) by Guillermo del Toro (both from Mexico).

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