The Kansas City Royals signed Melido as an undrafted free agent in 1983. He made his major league debut for the Kansas City Royals on September 4, 1987. In that game, Pérez pitched seven innings of shutout ball for the victory. On December 10, 1987, Melido was traded with Chuck Mount (minors), John Davis and Greg Hibbard to the Chicago White Sox for Floyd Bannister and Dave Cochrane.\n', '

In 4 seasons with the White Sox, Melido appeared in 147 games, starting 106, and pitching 713 innings while compiling a 44-45 record; all the highest cumulative totals he accrued with one team during his career.\n', '

In his first season at Chicago, Perez started 32 games, posting a 12-10 record with a 3.79 ERA. He finished 6th in the American League Rookie of the Year Award voting.\n', '

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