On June 2, 1994, Holtz was drafted by the California Angels in the 17th round of the 1994 Major League Baseball draft.
In an eight-season career, Holtz posted a 16–19 record with a 4.76 ERA and three saves in 353 relief appearances.
Following the bulk of his MLB career, Holtz played for the Yokohama BayStars of the Japanese Central League in 2005 and had a 0–1 mark with 4.38 ERA and 22 strikeouts in 24+2⁄3 innings of work. He came back to the majors to pitch in three games for the Red Sox in 2006.

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