Ephraim was born in Philadelphia, Pennsylvania and grew up in Bucks County, Pennsylvania. She performed in shows at the Bucks County Playhouse as a child and in professional productions at the Prince Music Theater and Arden Theatre Company in Philadelphia as a teenager. Ephraim was raised Jewish.\n', '

In 2008, Ephraim graduated from Princeton University with a B.A. in Religious Studies. At Princeton she was a member of the Triangle Club and performed in and choreographed various shows for Princeton University Players and Theatre Intime.\n', '

Ephraim made her Broadway debut as Little Red Riding Hood in the Broadway revival of Into the Woods in 2002, receiving a Drama League Award nomination. She later played Bielke in a Broadway revival of Fiddler on the Roof (2004). Off-Broadway, Ephraim played Rachel Stein in End Days at the Ensemble Studio Theatre in 2009. She played Olive in The 25th Annual Putnam County Spelling Bee at the Barrington Stage Company in 2008, in a remounting of the production with new direction by Jeremy Dobrish, and at the North Shore Music Theatre. In 2010, she played Anne Frank in The Diary of Anne Frank at the Westport Country Playhouse.\n', '

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