Stephens was born July 2, 1949 in Rusk, Texas. Stephens attended the Connecticut College, from which she graduated in 1967.
A life member of The Actors Studio, Stephens starred in the soap opera Bright Promise as Jennifer Matthews from 1969–1970; her first role in a television series. She later appeared in the soap opera Days of Our Lives as Mary Anderson in 1975.
Stephens made her film debut in 1978 in John Carpenter's classic horror Halloween, playing the supporting role of Nurse Marion Chambers, who was attacked by Michael Myers in the film's early scenes. She was cast in John Carpenter's next film in 1981, Escape from New York, and later that year, reprised her role as Marion with the sequel Halloween II, having a much more significant presence on-screen. She appeared in several films such as American Dreamer, Russkies, and D2: The Mighty Ducks, before appearing for the third time as Marion Chambers in Halloween H20: 20 Years Later, the seventh film in the franchise. In 2002 she appeared in A Time for Dancing. Stephens has made guest appearances on many sitcoms such as All in the Family, CHiPs, Cheers, Ally McBeal, and Boston Legal. She reprised the role of Marion again in David Gordon Green's 2021 sequel Halloween Kills, with her character in the rebooted continuity again being killed by Myers (as she was in H20).

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